Tay Sachs More Condition_symptoms In Tay Sachs...why Does The Enlargement Of The Lysosomes Cause The Neurons To Die?

In Tay Sachs...why does the enlargement of the lysosomes cause the neurons to die? - tay sachs more condition_symptoms

So far, we know that the Tay-Sachs disease is caused by a lack of hexosaminidase-A, including the glycolipids in the lysosomes. This would explain the enlargement of the lysosomes, but cause of how and why the enlargement of the lysosomes to neuronal death? Thank you in advance for your answers.